Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
Identifieur interne : 000394 ( Pmc/Curation ); précédent : 000393; suivant : 000395Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
Auteurs : Cristina García-Delaney [Espagne] ; Maria-Ángeles Sánchez-Garcés [Espagne] ; Rui Figueiredo [Espagne] ; Alba Sánchez-Torres [Espagne] ; Cosme Gay-Escoda [Espagne]Source :
- Medicina Oral, Patología Oral y Cirugía Bucal [ 1698-4447 ] ; 2015.
Abstract
Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.
A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.
The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (
IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.
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DOI: 10.4317/medoral.20655
PubMed: 26449434
PubMed Central: 4670255
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as a predictor of peri-implantitis: A case-control study</title><author><name sortKey="Garcia Delaney, Cristina" sort="Garcia Delaney, Cristina" uniqKey="Garcia Delaney C" first="Cristina" last="García-Delaney">Cristina García-Delaney</name><affiliation wicri:level="1"><nlm:aff id="A1">DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Garces, Maria Ngeles" sort="Sanchez Garces, Maria Ngeles" uniqKey="Sanchez Garces M" first="Maria-Ángeles" last="Sánchez-Garcés">Maria-Ángeles Sánchez-Garcés</name><affiliation wicri:level="1"><nlm:aff id="A2">MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Figueiredo, Rui" sort="Figueiredo, Rui" uniqKey="Figueiredo R" first="Rui" last="Figueiredo">Rui Figueiredo</name><affiliation wicri:level="1"><nlm:aff id="A3">DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Torres, Alba" sort="Sanchez Torres, Alba" uniqKey="Sanchez Torres A" first="Alba" last="Sánchez-Torres">Alba Sánchez-Torres</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gay Escoda, Cosme" sort="Gay Escoda, Cosme" uniqKey="Gay Escoda C" first="Cosme" last="Gay-Escoda">Cosme Gay-Escoda</name><affiliation wicri:level="1"><nlm:aff id="A5">MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26449434</idno><idno type="pmc">4670255</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670255</idno><idno type="RBID">PMC:4670255</idno><idno type="doi">10.4317/medoral.20655</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000394</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000394</idno><idno type="wicri:Area/Pmc/Curation">000394</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000394</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical significance of interleukin-1 genotype in smoking patients
as a predictor of peri-implantitis: A case-control study</title><author><name sortKey="Garcia Delaney, Cristina" sort="Garcia Delaney, Cristina" uniqKey="Garcia Delaney C" first="Cristina" last="García-Delaney">Cristina García-Delaney</name><affiliation wicri:level="1"><nlm:aff id="A1">DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Garces, Maria Ngeles" sort="Sanchez Garces, Maria Ngeles" uniqKey="Sanchez Garces M" first="Maria-Ángeles" last="Sánchez-Garcés">Maria-Ángeles Sánchez-Garcés</name><affiliation wicri:level="1"><nlm:aff id="A2">MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Figueiredo, Rui" sort="Figueiredo, Rui" uniqKey="Figueiredo R" first="Rui" last="Figueiredo">Rui Figueiredo</name><affiliation wicri:level="1"><nlm:aff id="A3">DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Torres, Alba" sort="Sanchez Torres, Alba" uniqKey="Sanchez Torres A" first="Alba" last="Sánchez-Torres">Alba Sánchez-Torres</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gay Escoda, Cosme" sort="Gay Escoda, Cosme" uniqKey="Gay Escoda C" first="Cosme" last="Gay-Escoda">Cosme Gay-Escoda</name><affiliation wicri:level="1"><nlm:aff id="A5">MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona</wicri:regionArea></affiliation></author></analytic><series><title level="j">Medicina Oral, Patología Oral y Cirugía Bucal</title><idno type="ISSN">1698-4447</idno><idno type="eISSN">1698-6946</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.</p></sec><sec><title>Material and Methods</title><p>A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.</p></sec><sec><title>Results</title><p>The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (<italic>p</italic>=0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.</p></sec><sec><title>Conclusions</title><p>IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.</p><p><bold>Key words:</bold>Peri-implantitis, interleukin-1 genotype positive, case-control study, smoking.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey=" Cosyn, J" uniqKey=" Cosyn "> J Cosyn </name></author><author><name sortKey=" Christiaens, V" uniqKey=" Christiaens "> V Christiaens </name></author><author><name sortKey=" Koningsveld, V" uniqKey=" Koningsveld "> V Koningsveld </name></author><author><name sortKey=" Coucke, Pj" uniqKey=" Coucke "> PJ Coucke </name></author><author><name sortKey=" De Coster, P" uniqKey=" De Coster "> P De Coster </name></author><author><name sortKey=" De Paepe, A" uniqKey=" De Paepe "> A De Paepe </name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, J" uniqKey="Liao J">J Liao</name></author><author><name sortKey="Li, C" uniqKey="Li C">C 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Buser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gruica, B" uniqKey="Gruica B">B Gruica</name></author><author><name sortKey="Wang, Hy" uniqKey="Wang H">HY Wang</name></author><author><name sortKey="Lang, N" uniqKey="Lang N">N Lang</name></author><author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Oral Patol Oral Cir Bucal</journal-id><journal-id journal-id-type="iso-abbrev">Med Oral Patol Oral Cir Bucal</journal-id><journal-id journal-id-type="publisher-id">Medicina Oral S.L.</journal-id><journal-title-group><journal-title>Medicina Oral, Patología Oral y Cirugía Bucal</journal-title></journal-title-group><issn pub-type="ppub">1698-4447</issn><issn pub-type="epub">1698-6946</issn><publisher><publisher-name>Medicina Oral S.L.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26449434</article-id><article-id pub-id-type="pmc">4670255</article-id><article-id pub-id-type="publisher-id">20655</article-id><article-id pub-id-type="doi">10.4317/medoral.20655</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject><subj-group><subject>Oral Surgery</subject></subj-group></subj-group></article-categories><title-group><article-title>Clinical significance of interleukin-1 genotype in smoking patients
as a predictor of peri-implantitis: A case-control study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>García-Delaney</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sánchez-Garcés</surname><given-names>Maria-Ángeles</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Figueiredo</surname><given-names>Rui</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sánchez-Torres</surname><given-names>Alba</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Gay-Escoda</surname><given-names>Cosme</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</aff><aff id="A2"><label>2</label>MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</aff><aff id="A3"><label>3</label>DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</aff><aff id="A4"><label>4</label>DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</aff><aff id="A5"><label>5</label>MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona, Spain</aff><author-notes><corresp> Faculty of Dentistry. Campus de Bellvitge
University of Barcelona
C/ Feixa Llarga, s/n
Pavelló Govern, 2ª planta, Despatx 2.9
08907 L’Hospitalet de Llobregat
Barcelona Spain
, E-mail: <email>rui@ruibf.com </email></corresp><fn id="FN1" fn-type="conflict"><p><bold>Conflict of interest statement:</bold> The authors have declared that no conflict of interest exist.</p></fn></author-notes><pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>9</day><month>10</month><year>2015</year></pub-date><volume>20</volume><issue>6</issue><fpage>e737</fpage><lpage>e743</lpage><history><date date-type="accepted"><day>21</day><month>5</month><year>2015</year></date><date date-type="received"><day>5</day><month>2</month><year>2015</year></date></history><permissions><copyright-statement>Copyright: © 2015 Medicina Oral S.L.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.</p></sec><sec><title>Material and Methods</title><p>A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.</p></sec><sec><title>Results</title><p>The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (<italic>p</italic>=0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.</p></sec><sec><title>Conclusions</title><p>IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.</p><p><bold>Key words:</bold>Peri-implantitis, interleukin-1 genotype positive, case-control study, smoking.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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